FLT3 (FMS-like tyrosine kinase 3)
نویسنده
چکیده
Size: 993 amino acids; 112804 Da; FLT3 is a class III receptor tyrosine kinase (RTK) structurally related to the receptors for platelet derived growth factor (PDGF), colony stimulating factor 1 (CSF1), and KIT ligand (KL).; these RTK contain five immunoglobulin-like domains in the extracellular region and an intracelular tyrosine kinase domain splitted in two by a specific hydrophilic insertion (kinase insert); immunoprecipitation of the human FLT3 protein results in the appearance of a minor band of Mr 130 000 and a major band of Mr 155 000/160 000; the highmolecular-weight band corresponds to the mature, Nglycosylated form, and the low-molecular-weight band to the immature, high mannose-containing form; Nlinked glycosylations account for 50 000 daltons.
منابع مشابه
FMS-like Tyrosine Kinase-3 Mutation in a Child with Standard-risk ALL and Normal Karyotype
FMS-like tyrosine kinase-3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is important for the normal development of stem cells and the immune system. Mutations of FMS-like tyrosine kinase-3 have been detected in about 30% of patients with acute myelogenous leukemia and a small number of patients with acute lymphoblastic leukemia. The FMS-like tyrosine kinase-3 muta...
متن کاملCytogenetic and FMS-Like Tyrosine Kinase 3 Mutation Analyses in Acute Promyelocytic Leukemia Patients
Background: The secondary genetic changes other than the promyelocytic leukemia-retinoic acid receptor (PML-RARA) fusion gene may contribute to the acute promyelocytic leukemogenesis. Chromosomal alterations and mutation of FLT3 (FMS-like tyrosine kinase 3) tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia. However, the prognostic significance of FLT3 mutat...
متن کاملبررسی جهش های ژن ( FLT3 (FMS like tyrosine kinase 3 درکودکان مبتلا به لوسمی های حاد
سابقه و هدف: جهش ژن flt3 (گیرنده تیروزین کینازی شبه) FMS باعث تکثیر بدون کنترل سلول های لوسمیک شده و پیش آگهی بدی را به همراه دارد. هدف ما از این مطالعه اجرایی کردن آزمایشات مولکولی برای تشخیص و غربالگری این جهش ها در مبتلایان لوسمی های حاد بود.روش بررسی: در این مطالعه بنیادی، 91 کودک مبتلا به لوسمی های حاد میلوئیدی (AML) و لنفوئیدی (ALL) از نظر جهش در ژن flt3 شامل وجود جهش ITD (Internal Tandem...
متن کاملFrequency of FLT3 ITD and FLT3 TKD Mutations in Multiple Myeloma Patients (A Case Control Study)
Background and Aims: Multiple myeloma is a malignant proliferation of plasma cells derived from a single clone. The tumor, its products and the host response lead to organ damages. Some factors that are responsible in its pathogenesis are recognized. As FMS like Tyrosine Kinase 3 receptor (FLT3) mutation has been proved as a determining factor in leukemic patients the goal of this study was to ...
متن کاملActivating internal tandem duplication mutations of the fms-like tyrosine kinase-3 (FLT3-ITD) at complete response and relapse in patients with acute myeloid leukemia.
FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutations are among the most frequent molecular aberrations in patients with acute myeloid leukemia. We retrospectively analyzed 324 patients with acute myeloid leukemia treated with front-line induction chemotherapy between October 2004 and March 2010. Fifty-six patients had FLT3-ITD mutation at diagnosis. Fifty-one (91%) patien...
متن کاملUniform sensitivity of FLT3 activation loop mutants to the tyrosine kinase inhibitor midostaurin.
Small molecule inhibitors that target fms-like tyrosine kinase 3 (FLT3)-activating mutations have potential in the treatment of leukemias. However, certain mutations can simultaneously activate the tyrosine kinase, and confer resistance to small molecule inhibitors. We therefore tested the sensitivity of 8 FLT3 activation loop mutants to midostaurin. Each mutant conferred IL-3 factor-independen...
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